Manchester United side will play their first leg match against the Spanish side Celta Vigo on Thursday and in the first match, they are ready to miss out their seven regular team players against them.
In their last match against Swansea City, the two Manchester United players added themselves to their injury list (Luke Shaw and Eric Bailly).
Along with Bailly Jones and Smalling and Marcos Rojo also in the injury list, it seems that Mourinho will not get any senior recognized center half against Celta Vigo.
But on a good note, Juan Mata was on the bench for them in their last match against Swansea and everyone is hoping that he will play a pivotal role in their Europa league match against the Spanish side.
Paul Pogba will set to play against their Spanish outfit but their main man Zlatan Ibrahimovic will miss out and along with him Marcos Rojo and Timothy Fosu-Mensah are out too.
Ashley Young believes because of their hectic schedule this happens to them.
He voiced: "I think there were a lot of tired legs in the second half, but there are still a lot of points to play for.
"We have to recover and we have another game to look forward to. Getting the injuries isn't ideal, but we have to keep plugging away."
On the other hand, Celia's coach told his players to forget about their last defeat against the Athletic Bilbao and try to focus on their next match against the Red Devils.
He urged his crew to rise against the Manchester United side to the occasion.
He voiced: "We all have to go together, hand in hand, imagining about a dream result,"
"To be able to accomplish the dream should stimulate everyone to try to overcome a great team by giving a great effort.
"I really hope we experience a special night."